ETIOLOGIES OF RESTLESS LEGS SYNDROME

Idiopathic disease

Secondary disease

     Nutritional deficiency

          Iron deficiency

          Folate deficiency

          Hypomagnesemia

     Peripheral neuropathy

          Alcoholic

          Amyloidosis

          Chronic inflammatory demyelinating polyradiculoneuropathy

          Diabetes mellitus

          Lyme disease

          Rheumatoid arthritis

          Sjogren’s syndrome

          Uremia

          Vitamin B12 deficiency

     Pregnancy

     Anemia

     Parkinson’s disease

     Gastric surgery

     Chronic obstructive pulmonary disease (COPD)

     Carcinoma

     Chronic venous insufficiency/ varicose veins

     Diet

          Alcohol

          Caffeine

     Medications

          methsuximide

          phenytoin

          amitriptyline HCl

          paroxetine HCl

          beta blockers

          histamine2 antagonists

          lithium

          neuroleptics

     Cigarette smoking

     Myelopathy/ myelitis

     Hypothyroidism

     Hyperthyroidism

     Acute intermittent porphyria

     Fibromyalgia syndrome

     Arborizing telangiectasia of the lower limbs

     Cholesterol microemboli of the peripheral vasculature